Guests at Space City Comic Con 2016
- William Shatner
- Alex Kingston
- Billie Piper
- Ryan Hurst
- Ron Perlman
- Jason David Frank
- Tommy Flanagan
- Patrick Scott Patterson
- Fleet 31 – USS Constancy
- Dagorath LARP
- The 1701st Fleet – South Texas Squadron
- Star Wars Enthusiasts of Houston – Fan Meetup
- Cody Saintgnue
- Emilio Rivera
- Marina Sirtis
- Michael Dorn
- Eddie McClintock
- Mark Boone Jr
- Rene Auberjonois
- Adrian Paul
- Doug Jones
- Simon Fisher-Becker
- Rusty Coones
- Eddie Newsome
- Virginia Hey
- Michael Welch
- Gigi Edgley
- Sandahl Bergman
- Julian Glover
- Dirk Benedict
- Michele Specht
- Chris Doohan
- Shawn Ashmore
- D-Piddy
- Titan Cosplay
- Gerardo Sandoval
- Liam Sharp
- Brent Spiner